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College of Arts & Sciences
Department of Statistics


Enrique Schisterman

Thursday, November 10, 2016 - 2:45pm

Statistics Department Colloquium

Where: LeConte College, Room 210

Speaker: Enrique Schisterman

Affiliation: National Institute of Child Health and Human Development, National Institutes of Health

Title: Pooling Bio-Markers as a Cost-Effective Design

Abstract:

Evaluating biomarkers in epidemiological studies can be expensive and time consuming. Many investigators use techniques such as random sampling or pooling biospecimens in order to cut costs and save time on experiments. Commonly, analyses based on pooled data are strongly restricted by distributional assumptions that are challenging to validate because of the pooled biospecimens. Random sampling provides data that can be easily analyzed. However, random sampling methods are not optimal cost-efficient designs for estimating means. We propose and examine a cost-efficient hybrid design that involves taking a sample of both pooled and unpooled data in an optimal proportion in order to efficiently estimate the unknown parameters of the biomarker distribution.