Ray Carroll Palmetto Lecture 2Friday, March 24, 2017 - 2:30pm
2017 Palmetto Lecture II (part of the South Carolina ASA meeting)
Where: Discovery Building, Room 140
Speaker: Raymond Carroll
Affiliation: Texas A&M University, Department of Statistics
Title: Constrained maximum likelihood estimation for model calibration using summary-level information from external big data sources
Abstract: Information from various public and private data sources of extremely large sample sizes is now increasingly available for research purposes. Statistical methods are needed for utilizing information from such big data sources while analyzing data from individual studies that may collect more detailed information required for addressing specific hypotheses of interest. We consider the problem of building regression models based on individual-level data from an ``internal'' study while utilizing summary-level information, such as information on parameters for reduced models, from an ``external'' big-data source. We identify a set of very constraints that link internal and external models. These constraints are used to develop a framework for semiparametric maximum likelihood inference that allows the distribution of the covariates to be estimated using either the internal sample or an external reference sample. We develop extensions for handling complex stratified sampling designs, such as case-control sampling, for the internal study. Asymptotic theory and variance estimators are developed for each case. We use simulation studies and a real data application to assess the performance of the proposed methods.